Carbon 4 synthesis of aspirin from salicylic acid salicylic acid acetic anhydride sodium acetate acetylsalicylic acid acetic acid molecular mass 13812 g mol-1 10209 g mol-1 8203 g mol-1 18016 g mol-1 6005 g mol-1 stoichiometry 1 1 (3, excess) (catalyst) 1 1. Procedure: microscale synthesis of acetylsalicylic acid (aspirin) acetyl salicylic acid mw18015 mp 128-137 oc acetic anhydride mw10209 mp 140 oc salicylic acid mw 13812 mp 159 o h3po4 + o o ch3 o oh o o o h3c h3c oh o oh • using a hot plate, heat water in a beaker. Synthesis of aspirin ling tecson gamido, mitchiko mariel m mizukami abstract acetylsalicylic acid, or also known as aspirin is known to be a drug that relives people of pain and is commonly used even today. The chemical name for aspirin is acetylsalicylic acid it is an ester theory: preparing esters from an alcohol and a carboxylic acid using an acid as catalyst is one of the most useful reactions in an organic chemists toolbox in this experiment, you will prepare aspirin from salicylic acid and acetic anhydride using sulfuric acid as a. Acetylsalicylic acid is used as analgesic, antipyretic, anticoagulant and anti-rheumatic it is also used as an additive in food, animal feed, drug and cosmetic low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or death of cardiac tissue.
Synthesis of acetylsalicylic acid (aspirin) anna shahrour partner jocelyn barraza ta yong wang section 05 introduction aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever reducer and as a painkiller. Hua 2 i introduction the aim of the experiment is to synthesize acetylsalic acid (aspirin), from salicylic acid and acetic anhydride, and to compare is characteristics to commercially available aspirin an ester group is an important functional group that can be synthesized via a number of different way 1the reaction of carboxylic acid and alcohol with the presence of a catalyst such as. Aspirin is the most widely used over-the-counter drug in the world the average tablet contains about 325 milligrams of the active ingredient acetylsalicylic acid with an inert binding material such as starch. The theoretical yield of aspirin in trial 1 was found by finding the limiting reagent, salicylic acid, and then multiplying the number of moles of aspirin that can be produced by the molar mass of aspirin, as there is a 1:1 stoichiometric ratio between salicylic acid and aspirin.
And acetylsalicylic acid (aspirin, asa) using principles of green chemistry, namely solvent-free synthesis combined with microwave-energy irradiation the synthesis was carried out using salicylic acid and 4. Hoffmann, a chemist in the pharmaceutical laboratory of the german dye manufacturer friedrich bayer & co in elberfeld, consulted the chemical literature and came across the synthesis of acetylsalicylic acid and then prepared the first sample of pure acetylsalicylic acid on 10 august 1897. The chemical equation for the synthesis of aspirin is c7h6o3 + c4h6o3 – c9h8o4 +c2h4o2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. Esterification reaction: the synthesis and purification of 2-acetoxybenzoic acid and subsequent analysis of the pure the active ingredient of the drug aspirin, acetylsalicylic acid can be synthesized through synthesis of aspirin 2009 grams of salicylic acid was used with 5000 ml of acetic anhydride.
Acetylsalicylic acid, also known as aspirin, is one of the most widely used medications to reduce fever and is also used as a pain killer it is an acetyl derivative of salicylic acid it is a white, crystalline, weakly acidic substance which melts at 135°c. Aspirin, or acetyl salicylic acid, belongs to a group of organic compounds known as esters aspirin is an aspirin is an analgesic (painkiller), an antipyretic (fever reducer), and an anti-inflammatory agent. Aspirin synthesis lab report 2 8 9 the objective of this lab was to determine the purity of the synthesized aspirin by determining the percentage of acetylsalicylic acid present in the product 2 balanced equation step 1 and to qualitatively determine the purity of the aspirin by finding the percentage of acetylsalicylic acid in the.
Abstract: this laboratory project involves the synthesis, characterization, and study of some reactions of acetylsalicylic acid, and the comparison of acetylsalicylic acid with the major components of various commercial brands of aspirin tablets. -in the synthesis of aspirin, you will treat salicylic acid with acetic anhydride -in order to proceed, the reaction requires an acid catalyst - phosphoric acid -in this lab, we will be using 90% of our salicylic acid to synthesize aspirin. Aspirin is salicylic ester of acetic acid and can be prepared by reaction of salicylic acid with acetic acid catalyzed by acid however this reaction is reversible one and after attaining equilibrium may reverse leading to hydrolysis of ester as shown in figure below.
Exp’t 80 synthesis of acetylsalicylic acid (aspirin) fromk l williamson, macroscale and microscale organic experiments, 2nd ed 1994, houghton mifflin, boston p379 revised 10/18/06 prelab exercise write a detailed mechanism of the following acid-catalyzed reaction, the formation of aspirin. Comprehensive disease interaction information for acetylsalicylic acid includes aspirin - coagulation comprehensive disease interaction information for acetylsalicylic acid all salicylates can interfere with the action of vitamin k and induce a dose-dependent alteration in hepatic synthesis of coagulation factors vii, ix and x at usual. Acetylsalicylic acid is absorbed from the intestine, it is converted back to salicylic acid it enters the bloodstream where it interferes with the synthesis of prostaglandins and irreversibly binds to an.